|
CYP2J2 allele nomenclature
Allele
|
Protein
|
Nucleotide changes
|
Effect
|
Enzyme activity
|
References
|
cDNA
|
Gene
|
In_vivo
|
In_vitro
|
CYP2J2*1
|
CYP2J2.1
|
None
|
None
|
|
Normal
|
Normal
|
|
CYP2J2*2
|
CYP2J2.2
|
427A>G
|
14488A>G
|
T143A
|
|
Reduced AA and LA
metabolism
|
King
et al., 2002
|
CYP2J2*3
|
CYP2J2.3
|
472C>T
|
14533C>T
|
R158C
|
|
Reduced AA and LA
metabolism
|
King
et al., 2002
|
CYP2J2*4
|
CYP2J2.4
|
575T>A
|
15029T>A
|
I192N
|
|
Reduced AA
metabolism
|
King
et al., 2002
|
CYP2J2*5
|
CYP2J2.5
|
1024G>A
|
21709G>A
|
D342N
|
|
Normal metabolism of AA
and LA
|
King
et al., 2002
|
CYP2J2*6
|
CYP2J2.6
|
1210A>T
|
25662A>T
|
N404Y
|
|
Reduced AA and LA
metabolism
|
King
et al., 2002
|
CYP2J2*7
|
CYP2J2.7
|
|
-76G>T
|
|
Decr.
|
Reduced transcription due
to loss of Sp1 binding site
|
King et al., 2002
Spiecker et al., 2004
|
CYP2J2*8
|
CYP2J2.8
|
934G>A
|
18892G>A
|
G312R
|
|
|
Shin et al., 2005
|
CYP2J2*9
|
CYP2J2.9
|
1052C>T
|
21737C>T
|
P351L
|
|
|
Shin et al., 2005
|
CYP2J2*10
|
CYP2J2.10
|
344C>T
|
10780C>T
|
P115L
|
|
|
Gaedigk et al., 2006
|
AA, arachidonic acid; LA, linoleic acid
Changes
made since the last update (27-Mar-2007)
are marked in red.
Links to the NCBI dbSNP
homepage are available for functional SNPs when present in NCBI's database.
Nucleotide variations in bold
are the major SNPs/alterations responsible for the phenotype of the
corresponding allele.
OMIM GeneCards
|