Allele
|
Protein
|
Nucleotide changes
|
Effect
|
Enzyme activity
|
References
|
cDNA
|
Gene
|
In_vivo
|
In_vitro
|
CYP4A22*1
|
CYP4A22.1
|
None
|
None
|
|
Normal
|
Normal
|
|
CYP4A22*2
|
CYP4A22.2
|
31C>T;
454A>T;
691T>C;
969C>T
|
31C>T;
4694A>T;
6332T>C;
7136C>T
|
R11C;
N152Y;
C231R
|
|
|
Hiratsuka
et al., 2006
|
CYP4A22*3A
|
|
31C>T;
454A>T;
691T>C;
900delG
|
31C>T:
4694A>T;
6332T>C;
7067delG
|
R11C;
N152Y;
C231R;
300Frameshift
|
|
|
Hiratsuka
et al., 2006
|
CYP4A22*3B
|
|
31C>T;
454A>T;
900delG
|
31C>T;
4694A>T;
7067delG
|
R11C;
N152Y;
300Frameshift
|
|
|
Hiratsuka
et al., 2006
|
CYP4A22*3C
|
|
454A>T;
691T>C;
900delG
|
4694A>T;
6332T>C;
7067delG
|
N152Y; C231R; 300Frameshift
|
|
|
Hiratsuka
et al., 2006
|
CYP4A22*3D
|
|
454A>T;
691T>C;
900delG; 1102C>T
|
4694A>T;
6332T>C;
7067delG; 7365C>T
|
N152Y; C231R; 300Frameshift
|
|
|
Hiratsuka
et al., 2006
|
CYP4A22*3E
|
|
454A>T;
691T>C;
900delG; 1283T>C
|
4694A>T;
6332T>C;
7067delG; 8441T>C
|
N152Y, C231R,
300Frameshift
|
|
|
Hiratsuka
et al., 2006
|
CYP4A22*4
|
CYP4A22.4
|
388G>A;
454A>T;
691T>C;
969C>T
|
4628G>A;
4694A>T;
6332T>C;
7136C>T
|
G130S; N152Y; C231R
|
|
|
Hiratsuka
et al., 2006
|
CYP4A22*5
|
CYP4A22.5
|
454A>T;
691T>C;
969C>T
|
4694A>T;
6332T>C;
7136C>T
|
N152Y; C231R
|
|
|
Hiratsuka
et al., 2006
|
CYP4A22*6
|
CYP4A22.6
|
454A>T;
691T>C;
1283T>C
|
4694A>T;
6332T>C;
8441T>C
|
N152Y; C231R; L428P
|
|
|
Hiratsuka
et al., 2006
|
CYP4A22*7
|
CYP4A22.7
|
454A>T;
691T>C;
969C>T; 1525C>T
|
4694A>T;
6332T>C;
7136C>T; 11277C>T
|
N152Y; C231R; L509F
|
|
|
Hiratsuka
et al., 2006
|
CYP4A22*8
|
CYP4A22.8
|
376C>T;
454A>T;
691T>C;
827A>C
|
4124C>T;
4694A>T;
6332T>C;
6908A>C
|
R126W; N152Y; C231R; K276T
|
|
|
Hiratsuka
et al., 2006
|
CYP4A22*9
|
CYP4A22.9
|
376C>T;
454A>T;
691T>C;
1283T>C
|
4124C>T;
4694A>T;
6332T>C;
8441T>C
|
R126W; N152Y; C231R; L428P
|
|
|
Hiratsuka
et al., 2006
|
CYP4A22*10
|
CYP4A22.10
|
388G>A;
454A>T;
553G>T;
691T>C;
1283T>C;
1525C>T
|
4628G>A;
4694A>T;
5826G>T;
6332T>C;
8441T>C;
11277C>T
|
G130S; N152Y; V185F; C231R; L428P; L509F
|
|
|
Hiratsuka
et al., 2006
|
CYP4A22*11
|
CYP4A22.11
|
376C>T;
454A>T;
553G>T;
691T>C;
827A>C;
1525C>T
|
4124C>T;
4694A>T;
5826G>T;
6332T>C;
6908A>C;
11277C>T
|
R126W; N152Y; V185F; C231R; K276T; L509F
|
|
|
Hiratsuka
et al., 2006
|
CYP4A22*12A
|
CYP4A22.12
|
376C>T;
388G>A;
454A>T;
553G>T;
691T>C;
1283T>C
|
4124C>T;
4628G>A;
4694A>T;
5826G>T;
6332T>C;
8441T>C
|
R126W; G130S; N152Y; V185F; C231R; L428P
|
|
|
Hiratsuka
et al., 2006
|
CYP4A22*12B
|
CYP4A22.12
|
376C>T;
388G>A;
454A>T;
553G>T;
691T>C;
1170A>C; 1283T>C
|
4124C>T;
4628G>A;
4694A>T;
5826G>T;
6332T>C;
7433A>C; 8441T>C
|
R126W; G130S; N152Y; V185F; C231R; L428P
|
|
|
Hiratsuka
et al., 2006
|
CYP4A22*13A
|
CYP4A22.13
|
376C>T;
388G>A;
454A>T;
553G>T;
691T>C;
1283T>C;
1525C>T
|
4124C>T;
4628G>A;
4694A>T;
5826G>T;
6332T>C;
8441T>C;
11277C>T
|
R126W; G130S; N152Y; V185F; C231R; L428P; L509F
|
|
|
Hiratsuka
et al., 2006
|
CYP4A22*13B
|
CYP4A22.13
|
376C>T;
388G>A;
454A>T;
553G>T;
691T>C;
1170A>C; 1283T>C;
1525C>T
|
4124C>T;
4628G>A;
4694A>T;
5826G>T;
6332T>C;
7433A>C; 8441T>C;
11277C>T
|
R126W; G130S; N152Y; V185F; C231R; L428P; L509F
|
|
|
Hiratsuka
et al., 2006
|
CYP4A22*14
|
CYP4A22.14
|
376C>T;
388G>A;
454A>T;
553G>T;
691T>C;
827A>C;
1525C>T
|
4124C>T;
4628G>A;
4694A>T;
5826G>T;
6332T>C;
6908A>C;
11277C>T
|
R126W; G130S; N152Y; V185F; C231R; K276T; L509F
|
|
|
Hiratsuka
et al., 2006
|
CYP4A22*15
|
CYP4A22.15
|
376C>T;
388G>A;
454A>T;
553G>T;
691T>C;
827A>C;
1283T>C;
1525C>T
|
4124C>T;
4628G>A;
4694A>T;
5826G>T;
6332T>C;
6908A>C;
8441T>C;
11277C>T
|
R126W; G130S; N152Y; V185F; C231R; K276T; L428P; L509F
|
|
|
Hiratsuka
et al., 2006
|